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September 12, 2025Sri Lankan Journal of Infectious DiseasesOpen Access

Prevalence and molecular characterisation of 16S rRNA methyltransferase genes mediating aminoglycoside resistance in Gram-negative bacteria from cancer patients: A tertiary care study in India

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Authors

SMSowmya MurugesanKKK. KottarathilSSSajani Samuel

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Overview

Prospective cross-sectional study reveals high aminoglycoside resistance in Gram-negative bacteria in cancer patients, suggesting urgent intervention strategies.

Key Points

  • High prevalence of 16S rRNA methyltransferase genes was found in aminoglycoside-resistant Gram-negative bacteria, indicating significant treatment challenges.
  • Of the 267 aminoglycoside-resistant isolates, 134 (50%) carried 16S RMTase genes, with rmtB being the most common at 57 occurrences.
  • A prospective cross-sectional study was conducted across a tertiary care center with 592 isolates collected over a one-year period to assess resistance genes.
  • The findings underscore the pressing need for effective detection and management of multidrug-resistant infections in healthcare settings.

Cite This Study

Murugesan et al. (2025) studied this question.

synapsesocial.com/papers/68d41eca713b0b5dfea6772ahttps://doi.org/10.4038/sljid.v15i2.8779
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Also Consider

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  3. 3Emergence of multidrug resistant opportunistic pathogens : A study on gram negative isolates from cancer patients2025
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