This study reveals the intricate co-carriage of bla NDM and methyltransferases in Enterobacterales, suggesting significant implications for antimicrobial resistance management.
Key Points
Detection of mobile genetic elements co-carrying bla NDM and 16S-RMTase genes reveals significant resistance mechanisms.
Among 58 isolates examined, those carrying bla NDM-1 frequently co-located with armA and rmtC genes on various plasmids.
Short-read and long-read sequencing techniques identified diverse plasmids, emphasizing their role in the dissemination of resistance traits.
The spread of these plasmids across multiple species within healthcare highlights urgent needs for public health interventions.