September 10, 2025Antimicrobial Agents and ChemotherapyOpen Access

Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens

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Authors

DVDarija VidučićUniversity of Zagreb SOSonja Obranić MMMihaela MatovinaRudjer Boskovic Institute

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Implication

Analysis reveals that natural antibiotic producers’ methyltransferases impose lower fitness costs than clinical strains, suggesting implications for aminoglycoside resistance.

Key Points

Methyltransferases from clinical strains show higher fitness costs, reducing bacterial competitiveness and persistence.
Growth competition assays found that natural producers' methyltransferases significantly lower fitness costs compared to clinical counterparts.
Translational fidelity assays indicated that most methyltransferases lead to increased errors in protein synthesis, affecting bacterial survival.
Stress response experiments showed that clinical methyltransferases can enhance resistance to acidic stress while increasing vulnerability to hyperosmotic conditions.

Cite This Study

Vidučić et al. (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d64793e46 https://doi.org/10.1128/aac.00742-25

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Implication

Analysis reveals that natural antibiotic producers’ methyltransferases impose lower fitness costs than clinical strains, suggesting implications for aminoglycoside resistance.

Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens

Discussion

Member takes

Implication

Key Points

Cite This Study

Biological cost of aminoglycoside resistance Arm/Kam 16S rRNA methyltransferases from natural antibiotic producers and clinical pathogens

Discussion

Member takes

Implication

Key Points

Cite This Study

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