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August 25, 2025Saudi Pharmaceutical JournalOpen Access

Prevalence, toxin virulence genes and investigating the effect of mutations in the tetracycline gene (tetK) on the response of methicillin-resistant Staphylococcus aureus to antibiotics: a study in sickle cell disease patients in Riyadh, Saudi Arabia

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Authors

AAAdel A. AbdulmaneaNANaiyf S. AlharbiMFMohamed A. Farraga

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Overview

Analysis reveals diverse resistance genes in MRSA, indicating heightened treatment challenges for sickle cell disease patients.

Key Points

  • MRSA strains from sickle cell disease patients show varied resistance profiles, complicating treatment strategies.
  • 0.9% of SCD patients were found to have MRSA bloodstream infections, primarily in individuals over 20 years old.
  • Analysis involved genetic sequencing of resistance genes, highlighting significant mutations in the tetK gene.
  • Importance of ongoing monitoring for antibiotic susceptibility in high-risk populations, including patients with sickle cell disease.

Cite This Study

Abdulmanea et al. (2025) studied this question.

synapsesocial.com/papers/68af7c827567bf4f94ff35c2https://doi.org/10.1007/s44446-025-00033-3
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Also Consider

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