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September 12, 2025Open Access

Roasted Astragalus membranaceus Inhibits Cognitive Decline in 5xFAD Mice by Activating the BDNF/CREB Pathway

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Authors

JYJi Hye YoonJMJinyoung MaengYKYujin Kim

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Overview

This research demonstrates that roasted astragalus membranaceus improves cognitive function in 5xFAD mice, indicating potential benefits against Alzheimer's disease.

Key Points

  • Roasted astragalus membranaceus significantly improved working memory and reduced cognitive decline in 5xFAD mice over three months.
  • BDNF and p-CREB/CREB expression increased, while p-JNK/JNK levels decreased, illustrating the activation of the BDNF/CREB pathway.
  • Long-term water-extracted roasted astragalus was effective in lowering glucose and reducing anxiety behavior in the preclinical model.
  • The study suggests that roasting enhances the properties of astragalus membranaceus, making it beneficial for preventing neurodegenerative diseases.

Cite This Study

Yoon et al. (2025) studied this question.

synapsesocial.com/papers/68d418db713b0b5dfea64abdhttps://doi.org/10.20944/preprints202509.0930.v1
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