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June 21, 2026Journal of Medicinal Food

Standardized Artemisia argyi Extract Alleviates Scopolamine-Induced Memory Impairment in Mice

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Authors

SBSeung Hyun ByunKPKeontae ParkSMSomin Moon

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Overview

Randomized trial demonstrates cognitive enhancement in mice with scopolamine-induced impairment, suggesting a potential treatment alternative.

Key Points

  • The study investigates the memory-enhancing effects of an ethanolic extract of Artemisia argyi in a mouse model of cognitive dysfunction.
  • Administered ethanolic extract of Artemisia argyi (10, 30, or 100 mg/kg) in scopolamine-induced mice.
  • Assessed memory performance using Y-maze, novel object recognition, Morris water maze, and passive avoidance tests.
  • Evaluated signaling pathways via Western blotting to measure changes in CaMKII, ERK, CREB, and BDNF levels in the hippocampus.
  • EAA improved cognitive performance in all behavioral tests compared to control; detailed effects were not quantified in the abstract.
  • Restored phosphorylation levels of CaMKII, ERK, and CREB, and increased BDNF expression after treatment.
  • Enhanced long-term potentiation without affecting basal synaptic transmission in the hippocampus.

Cite This Study

Byun et al. (2026) studied this question.

synapsesocial.com/papers/6a37808224f042ddf4c5aa75https://doi.org/10.1177/1096620x261462220
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