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August 22, 2025Open Access

A novel arctigenin derivative ameliorates memory impairment and pathologies by activating adiponectin receptor 1-mediated autophagy and regulating amyloid precursor protein processing of Alzheimer's disease

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Authors

SLShangming LiBXBocheng XiongNXNan Xu

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Overview

Observational analysis shows ARC-18 improves cognitive function in 5xFAD mice, indicating autophagy activation may combat Alzheimer's disease progression.

Key Points

  • ARC-18 enhanced cognitive function and ameliorated memory impairment in 5xFAD mice, addressing Alzheimer's disease symptoms.
  • The behavioral performance improvements were observed through water maze and new object recognition tasks, indicating notable cognitive enhancements.
  • Analysis involved confirming ARC-18's effects on APP processing and autophagy markers in both mouse models and neuronal cell lines.
  • These findings suggest that targeting autophagy pathways could be vital in developing therapies for Alzheimer's disease.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af73567567bf4f94fec91dhttps://doi.org/10.21203/rs.3.rs-7035906/v1
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