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September 11, 2025Indonesian Journal of MedicineOpen Access

Antidiabetic and Anti-inflammatory Effects of Peperomia pellucida Leaf Extract: Modulation of Blood Glucose, IL-1β, and Pancreatic Histopathology in STZ-Induced Diabetic Rats

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Authors

RORia OktaviaEAEndy Juli AntoJSJekson Martiar Siahaan

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Overview

Experimental study demonstrates reduced blood glucose and inflammation in STZ-induced diabetic rats, suggesting potential for natural therapies.

Key Points

  • Ethanol extract of peperomia pellucida significantly lowers blood glucose levels in diabetic rats.
  • IL-1β levels decreased markedly in extract-treated groups, indicating anti-inflammatory effects.
  • Histopathological analysis revealed improved pancreatic structure at higher doses of extract.
  • Phytochemical screening identified key bioactive compounds, supporting the therapeutic utility of the extract.

Cite This Study

Oktavia et al. (2025) studied this question.

synapsesocial.com/papers/68d41734713b0b5dfea63b36https://doi.org/10.26911/theijmed.2025.10.3.870
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Histopathological Evaluation of Stomach Protection by Peperomia pellucida L. in Mice with Gastroenteritis2025
  2. 2Hepatic restorative potential of Portulaca oleracea ethanolic extract and/or metformin in type II diabetes mellitus model induced by high-fat diet and STZ2025 · 1 citations
  3. 3Phytochemical Screening and Antidiabetic Potential of <i>Paeonia emodi</i> in Alloxan‐Induced Diabetic Rats: Investigative Study Toward Possible Mechanism2025
  4. 4Synergistic Effect of Combined Leaf Extract of Vernonia amygdalina, Ocimum gratissimum, and Zingiber officinale Tuber on Phytochemical Profile, Antioxidant Activity, Serum Insulin, and Biochemical Parameters in Streptozotocin-Induced Diabetic Rats2025
  5. 5Immunomodulatory Activity of Chinese Betel (Peperomia pellucida L.) Extract on the Spleen Histopathology in a Murine Model of Gastroenteritis2025