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January 1, 2025Diabetes & Obesity International JournalOpen Access

Synergistic Effect of Combined Leaf Extract of Vernonia amygdalina, Ocimum gratissimum, and Zingiber officinale Tuber on Phytochemical Profile, Antioxidant Activity, Serum Insulin, and Biochemical Parameters in Streptozotocin-Induced Diabetic Rats

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Authors

FEFamakinwa EAOMOck MaAMAichi Ma

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Overview

Combination of Vernonia amygdalina, Ocimum gratissimum, and Zingiber officinale enhances antioxidant activity and improves serum insulin in diabetic rats, indicating potential treatment benefits.

Key Points

  • Blood glucose levels significantly dropped in diabetic rats treated with the combined extracts, enhancing metabolic control.
  • After 28 days, significant increases in body weight were observed in diabetic rats treated with the herbal combination and metformin.
  • Histological evaluations showed regeneration of pancreatic β-cells in diabetic rats receiving the combined extracts, unlike metformin therapy.
  • The combined extracts significantly improved lipid profiles in diabetic rats, suggesting a protective effect on cardiovascular health.

Cite This Study

EA et al. (2025) studied this question.

synapsesocial.com/papers/68af3e34cf1dd9ea359eac0fhttps://doi.org/10.23880/doij-16000297
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