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October 9, 2025Circulation Research

Abstract Wed120: Right Ventricle Fibroblasts Display a Hyperfibrotic Phenotype In Vitro

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Authors

MBMadeline BurghazeMGMatthew W. Gorr

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Overview

Experimental analysis reveals enhanced fibrosis and proliferation in right ventricle fibroblasts, suggesting distinct disease mechanisms.

Key Points

  • Right ventricle fibroblasts show significantly higher fibrotic gene expression compared to left ventricle fibroblasts, indicating a unique response to stress.
  • Quantitative PCR analysis revealed a 1.2 times higher fold-change in periostin expression in right ventricle fibroblasts stimulated by TGFβ than their left ventricle counterparts.
  • Seahorse assay results suggest that right ventricle fibroblasts have a greater oxygen consumption rate than left ventricle fibroblasts, highlighting their metabolic differences.
  • RNA-seq analyses indicate that right ventricle fibroblasts favor pathways linked to cell division, potentially driving their hyperfibrotic phenotype.

Cite This Study

Burghaze et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbffhttps://doi.org/10.1161/res.137.suppl_1.wed120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Right Ventricular Fibrosis With Pulmonary Arterial Hypertension2025
  2. 2Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension2025
  3. 3Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension2025 · 1 citations
  4. 4Abstract Thu147: The Complex Role of ROR2 in Fibroblast Activation and Tissue Mechanics2025
  5. 5Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy2026