Applying advanced imaging and computational fluid dynamics, this study finds altered hemodynamics in right ventricular failure with sex-based differences.
Key Points
Microvascular remodeling led to decreased hemodynamic resistance and wall shear stress in pressure-overloaded right ventricles.
Mice with pulmonary artery banding exhibited significant structural changes in the microvascular system compared to SHAM controls.
Sex-specific adaptations were noted, particularly in hemodynamic resistance, with males showing different responses post-injury.
Findings suggest adaptive roles of microvascular changes in preserving function and promoting perfusion in compromised right ventricles.