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August 19, 2025BiomedicinesOpen Access

The Transgenerational Impact of High-Fat Diet and Diabetic Pregnancy on Embryonic Transcriptomics and Mitochondrial Health

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Authors

AKA K KleinBDBenjamin P. DerengeMMMalini Mukherjee

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Overview

Observational analysis shows transcriptomic variations in embryos across generations, indicating long-term metabolic implications.

Key Points

  • HF+DM pregnancy alters the embryonic transcriptome across three generations, impacting cell fate.
  • F2 embryos from HF+DM pregnancies showed oxidative stress but more cells, while F3 embryos had adaptive responses.
  • Single-cell RNA sequencing assessed embryos revealing differential gene expression in lipid metabolism and mitochondria.
  • Findings highlight the influence of maternal diet and diabetes on embryonic development and genomic repair, pointing to a major public health concern.

Cite This Study

Klein et al. (2025) studied this question.

synapsesocial.com/papers/68af35e3cf1dd9ea359ea118https://doi.org/10.3390/biomedicines13082019
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