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September 20, 2025Nature CommunicationsOpen Access

Genetic architecture of plasma metabolome in 254,825 individuals

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Authors

YQYi‐Xuan QiangYWYixuan WangXHXiaoyu He

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Overview

Genome-wide association study identifies thousands of variant-metabolite associations, suggesting genetic influence on metabolic measures.

Key Points

  • Identified 24,438 independent variant-metabolite associations across 427 loci, highlighting the genetic basis of the plasma metabolome.
  • Utilized fine-mapping techniques to pinpoint 3610 putative causal associations, including 785 novel findings relevant to metabolic diseases.
  • Whole exome sequencing recovered 2948 gene-metabolite associations, underscoring the importance of rare coding variants in metabolomics research.
  • Findings indicate potential links between acetate levels and atrial fibrillation risk, emphasizing implications for disease mechanisms.

Cite This Study

Qiang et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea61831https://doi.org/10.1038/s41467-025-62126-w
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