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September 20, 2025Nature MetabolismOpen Access

Mapping the plasma metabolome to human health and disease in 274,241 adults

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Authors

JYJia YouXCXi-Han CuiYCYilin Chen

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Overview

This atlas reveals strong links between plasma metabolites and diseases in a biobank of 274,241 adults, suggesting implications for precision medicine.

Key Points

  • A total of 52,836 metabolite–disease associations were uncovered, enhancing understanding of health and disease.
  • The study identified 313 plasma metabolites linked to 1,386 diseases, showing the potential for a metabolome–phenome atlas.
  • Machine-learning methods highlighted 30 key metabolites as biomarkers with effective classification for diseases.
  • Mendelian randomization analyses confirmed causal relationships for 454 metabolite–disease pairs, emphasizing shared genetic factors.

Cite This Study

You et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea61832https://doi.org/10.1038/s42255-025-01371-1
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Also Consider

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  1. 1Genetic architecture of plasma metabolome in 254,825 individuals2025 · 4 citations