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December 8, 2025Blood

Exploring the disease impact of plasma metabolites on marginal zone lymphoma based on mendelian randomization

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KLKang Lu

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Overview

Mendelian Randomization identifies protective and risk plasma metabolites in marginal zone lymphoma, suggesting new pathways for disease insights.

Key Points

  • Plasma metabolites significantly impact marginal zone lymphoma risk and protection, particularly mta and X-21471.
  • A genome-wide association study assessed 1,400 plasma metabolites, revealing key differential expressions in MZL patients.
  • Utilizing Mendelian Randomization, instrumental variables were selected for SNP annotation and associated gene identification.
  • The findings highlight potential metabolic pathways and call for further studies to elucidate disease mechanisms.

Cite This Study

Kang Lu (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d71ahttps://doi.org/10.1182/blood-2025-7122
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  4. 4Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia2025
  5. 5Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study2025