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August 6, 2025Open Access

Metabolomics Ex/GWAS in the Amish reveals novel insights into cardiometabolic disease pathways

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Authors

MJMomodou W. JallowGTGannie TzonevaBYBin Ye

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Overview

Exome and GWAS identify genetic variants affecting metabolite levels in Amish adults, highlighting cardiometabolic disease pathways.

Key Points

  • MAIN FINDING: The study uncovered 149 genetic variants associated with metabolite levels linked to cardiometabolic disease.
  • KEY EVIDENCE: 69 genetic variants were found significantly enriched in the Amish compared to European populations.
  • APPROACH: The research involved exome and genome-wide association studies on serum metabolites in 5,981 Amish adults.
  • SIGNIFICANCE: This work enhances understanding of genetic influences on cardiometabolic traits, particularly in the Amish population.

Cite This Study

Jallow et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d18d5https://doi.org/10.1101/2025.08.04.667775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exonic Variation and Its Clinical Impact in 7221 Old Order Amish2025
  2. 2Genetic architecture of plasma metabolome in 254,825 individuals2025 · 4 citations
  3. 3Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms2025
  4. 4Genomic structural equation modelling provides insights into the shared multivariate genetic architecture of cardio-kidney-metabolic syndrome components2025 · 1 citations
  5. 5Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us2025