August 13, 2025Brain and BehaviorOpen Access

DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis

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Discussion

Metabolomic analysis reveals hydrogen reduces DGKζ levels, balancing DAG and PA, implying potential therapeutic targets in sepsis.

Hydrogen significantly reduces DGKζ levels in septic mice, alleviating brain damage and restoring metabolic balance.
The study identifies 1476 metabolites with 131 metabolic biomarkers linked to glycerophospholipid metabolism processes.
Caecal ligation and puncture formed the sepsis model, followed by treatment with hydrogen to analyze metabolic changes.
The interaction between DGKζ and PTEN presents a potential therapeutic pathway for managing septic encephalopathy.

Bai et al. (2025) studied this question.

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