Rapidly progressive fatal hepatic failure due to IgM-related AL amyloidosis in Waldenström’s macroglobulinemia: an autopsy case report

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Rapid progression of hepatic failure occurred despite hematologic improvement from treatment.
A 66-year-old woman with WM showed massive IgM-κ amyloid deposition in multiple organs at autopsy.
Combination therapy with rituximab and bendamustine resulted in reduced serum IgM levels.
Findings emphasize the necessity for early detection and novel strategies in advanced organ involvement.

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Case report demonstrates rapid hepatic failure in a woman with IgM-related AL amyloidosis and WM, suggesting urgent detection is crucial.

Shibamiya et al. (2025) studied this question.

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