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August 17, 2025Middle East Journal of Medical Case Reports

Multiple Myeloma with Light-Chain Amyloidosis Involving Heart, Kidneys, and Nerves: A Challenging Case Report

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Authors

FFFarhana FaruqueSWShahryar WaheedNSNayan Ranjan Sarker

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Overview

Case report reveals multiple organ involvement in AL amyloidosis linked to multiple myeloma, suggesting urgent diagnosis is crucial.

Key Points

  • Diagnosis of systemic al amyloidosis with multiple myeloma led to cardiac and renal complications, indicating urgency for early diagnosis and treatment.
  • Key evidence includes the presence of nephrotic-range proteinuria (6.75 g/day) and elevated NT-proBNP (3900 pg/mL).
  • Assessment using renal biopsy and echocardiography confirmed amyloidosis with lambda deposits and restrictive cardiomyopathy, necessitating prompt intervention.
  • Highlighting the need for multidisciplinary management, this case underscores the challenges posed by concurrent malignancies like medullary thyroid carcinoma.

Cite This Study

Faruque et al. (2025) studied this question.

synapsesocial.com/papers/68a35335234c60ad5c20e919https://doi.org/10.36348/merjmcr.2025.v05i04.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Silent progression: cardiac amyloidosis unmasking IgG lambda myeloma in an elderly patient2026
  2. 2AL amyloidosis with cardiac involvement: a case report with literature review2025
  3. 3Beyond the Usual Suspects: Clinical and Pathological Insights From a Rare Case of Light Chain (AL) Amyloidosis in a Filipino Patient2025
  4. 4Primary Amyloidosis Unmasked by Gastric Biopsy: A Case Report2025 · 1 citations
  5. 5Difficulties in diagnosing and treating AL amyloidosis: a case from practice2025