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October 23, 2025DiagnosticsOpen Access

A Rare Combination: Cold Agglutinin Disease Followed by Waldenström Macroglobulinemia—A Case of Early Treatment Response

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Authors

AKAnna Kozub ANAleksandra NasiekThe Maria Sklodowska-Curie National Research Institute of Oncology NBNataliia BogunV. N. Karazin Kharkiv National University

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Implication

Case report shows early treatment response in a patient with cold agglutinin disease and waldenström macroglobulinemia, indicating effectiveness of combination therapy.

Key Points

Marked reduction in IgM levels to less than 0.4 g/L after treatment, showing significant clinical improvement.
Initial blood tests indicated cold agglutinin disease, confirmed by cold agglutinin titre of 1:2000 and direct antiglobulin test.
Treatment initiated with intravenous rituximab followed by bendamustine/rituximab protocol led to stable haemoglobin levels.
Highlights the need for awareness of coexisting conditions in patients presenting with anaemia and other symptoms.

Cite This Study

Kozub et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3d1c https://doi.org/10.3390/diagnostics15202654

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Implication

Case report shows early treatment response in a patient with cold agglutinin disease and waldenström macroglobulinemia, indicating effectiveness of combination therapy.

A Rare Combination: Cold Agglutinin Disease Followed by Waldenström Macroglobulinemia—A Case of Early Treatment Response

Discussion

Member takes

Implication

Key Points

Cite This Study

A Rare Combination: Cold Agglutinin Disease Followed by Waldenström Macroglobulinemia—A Case of Early Treatment Response

Discussion

Member takes

Implication

Key Points

Cite This Study

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