Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Current Neuropharmacology

Microglia-Neuron Interactions in Alzheimer’s Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

YMYujie MaXWXinyue WangMGMinghuang Gao

Discussion

Loading...

Member takes

Overview

Review discusses microglia-neuron interactions and their implications in neuronal degeneration in Alzheimer's disease.

Key Points

  • Microglia interactions with neurons can both protect and damage neurons, contributing to the progression of Alzheimer's disease.
  • Excessive synaptic pruning by microglia may exacerbate neuronal degeneration, affecting cognitive function in Alzheimer's disease.
  • The review highlights microglia's dual role in classical pathogenic hypotheses involving neuroinflammation and amyloid cascade.
  • Understanding microglia-neuron interactions could lead to novel therapeutic strategies for rescuing neurons in Alzheimer's disease.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a22bhttps://doi.org/10.2174/011570159x379539250807114252
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microglial Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapies2025 · 11 citations
  2. 2Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms2025 · 18 citations
  3. 3Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics2025 · 4 citations
  4. 4The Role of Microglial Cells and Cytokine Modulation in Alzheimer’s Disease: A Neuroinflammatory Perspective2026 · 3 citations
  5. 5Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions2025 · 25 citations