Retrospective analysis indicates overall survival in acute leukemia infants is influenced by minimal residual disease and remission status.
Key Points
Overall survival for infants with acute myeloid leukemia was significantly higher at 74.5% in first complete remission.
The prognosis for patients with acute lymphoblastic leukemia is positively impacted by minimal residual disease status prior to transplantation.
Assessment through flow cytometry was key in determining minimal residual disease prevalence among patients, affecting outcomes.
The findings support that allogeneic hematopoietic stem cell transplantation is viable for infant leukemias but highlights the importance of pre-transplant factors.