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December 8, 2025BloodOpen Access

Salvage allogeneic hematopoietic stem cell transplantation conditioning regimens for relapsed/refractory acute leukemia: Efficacy of radiotherapy combined with CLAG vs FLAG

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Authors

XMXiao‐Yong ManJWJingbo WangCCChun Chang

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Overview

Retrospective analysis reveals no significant survival differences using radiotherapy with CLAG or FLAG in relapsed acute leukemia, indicating validation is needed.

Key Points

  • Overall survival at 10 years was 32.9% in relapsed/refractory acute leukemia patients receiving allo-HSCT.
  • Cumulative incidence of relapse was observed at 34.5%, with no significant differences between treatments for overall survival or disease-free survival.
  • Retrospective analysis across 233 patients examined survival outcomes of conditioning with radiotherapy and chemotherapy regimens.
  • Findings suggest further validation is warranted for better survival outcomes in acute lymphoblastic leukemia patients using TBI-based regimens.

Cite This Study

Man et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3eahttps://doi.org/10.1182/blood-2025-2428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of FLAG and CLAG regimens (Replacing Cyclophosphamide) in conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory malignant hematologic diseases2025
  2. 2Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  3. 3Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen2025 · 1 citations
  4. 4Efficacy of thiotepa-containing conditioning regimens and mucositis burden in allogeneic HSCT for relapsed/refractory acute leukemia with extramedullary disease2025
  5. 5Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality2025