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September 10, 2025Journal of Cellular and Molecular MedicineOpen Access

Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies

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Authors

LSLuxiang ShangWWWeilin WangYLYiying Liu

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Overview

Systematic review evaluates proteomic biomarkers linked to atrial fibrillation risk in cohort studies, indicating functional networks. Biomarkers may guide future prevention strategies.

Key Points

  • Thirteen proteins were reproducibly associated with atrial fibrillation across at least two studies.
  • 111 proteins were identified across nine cohorts, with significant pathways related to extracellular matrix organization.
  • Mendelian randomisation analysis did not confirm causal relationships, suggesting proteins may reflect disease processes.
  • Interleukin‐6, matrix metalloproteinase‐2, and C‐reactive protein were identified as central network hubs in the protein interaction analysis.

Cite This Study

Shang et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a17c7https://doi.org/10.1111/jcmm.70760
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predicting atrial fibrillation in heart failure: added value of a plasma protein risk score over clinical and genomic models2026
  2. 2Large-Scale Plasma Proteomics Profiles for Predicting Atrial Fibrillation Associated Stroke Risk2026
  3. 3Biomarker panels for improved risk prediction and enhanced biological insights in patients with atrial fibrillation2025 · 12 citations
  4. 4Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases2025 · 1 citations
  5. 5Circulating Cardiovascular Proteomic Associations With Genetics and Disease2025