Why the study?
Does an 18-protein plasma risk score improve the prediction of incident atrial fibrillation over 4 years compared to established clinical and genomic models in patients with heart failure?
Population
3,289 patients with heart failure in the derivation cohort and 41,049 in the external validation cohort…
Comparison
18-protein plasma risk score derived via machine… vs Established clinical model and genomic model
Design
Cohort
Follow-up
4 years
Key result
A novel 18-protein plasma risk score predicted 4-year incident atrial fibrillation in heart failure patients independent of clinical profile (PRSD 1.69; 95% CI 1.40-2.1; p<0.0001).
Authors
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AF protein score may refine incident AF prediction; leaves open clinical utility pending prospective validation.
Cohort (n=3,289)
Yes
Does an 18-protein plasma risk score improve the prediction of incident atrial fibrillation over 4 years compared to established clinical and genomic models in patients with heart failure?
Effect estimate: PRSD 1.69 (95% CI 1.40-2.1)
p-value: p=<0.0001
A novel 18-protein plasma risk score improves the prediction of 4-year incident atrial fibrillation in heart failure patients compared to established clinical and genetic models.
Huttelmaier et al. (2026) conducted a cohort in Heart failure (n=3,289). AF protein score vs. CHARGE-AF and AF-PRS models was evaluated on Incident atrial fibrillation over 4 years (PRSD 1.69, 95% CI 1.40-2.1, p=<0.0001). A novel 18-protein plasma risk score predicted 4-year incident atrial fibrillation in heart failure patients independent of clinical profile (PRSD 1.69; 95% CI 1.40-2.1; p<0.0001).