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September 10, 2025Microbial GenomicsOpen Access

Plasmid genomic epidemiology of bla NDM carbapenemase-producing Enterobacterales in Canada from 2010 to 2023

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Authors

NLNicole A. LerminiauxPublic Health Agency of CanadaKFKen FakharuddinYLYves Longtin

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Implication

Whole-genome sequencing reveals diverse bla NDM plasmids in Enterobacterales, suggesting limited horizontal gene transfer across Canada.

Key Points

  • The study found a diverse array of bla NDM plasmids in Enterobacterales, indicating limited transmission across Canada.
  • Among 1,032 isolates, 69% (156/226) of complete plasmids were identified as IncF-type, with co-harboring genes detected.
  • Whole-genome sequencing integrated short-read and long-read methods, essential for understanding bla NDM plasmid structure.
  • Analysis suggests horizontal gene transfer has not significantly contributed to bla NDM spread in Canada.

Cite This Study

Lerminiaux et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479d37bhttps://doi.org/10.1099/mgen.0.001415
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolution, dissemination, and genetic dynamics of the carbapenem resistance gene blaNDM in China2025
  2. 2Phylogenetic analysis of bla NDM genes of carbapenem resistant uropathogens isolated from federal tertiary care hospital, Pakistan: insights into the evolution and dissemination of drug resistance2025
  3. 3Healthcare-related transmission of mobile genetic elements co-carrying bla NDM and 16S rRNA methyltransferase genes in multiple Enterobacterales2025
  4. 4Global phylogeography and genomic characterization of <i>bla</i> <sub>NDM-1</sub> -positive clinical <i>Proteus mirabilis</i> isolates from China2025
  5. 5Emergence and Polyclonal Dissemination of <i>bla</i><sub>NDM-7</sub>–Carrying InX3 Plasmid in <i>Enterobacter cloacae</i> Complex, France, 2021–20232025