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October 15, 2025Iranian Journal of MicrobiologyOpen Access

Phylogenetic analysis of bla NDM genes of carbapenem resistant uropathogens isolated from federal tertiary care hospital, Pakistan: insights into the evolution and dissemination of drug resistance

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Authors

MSMuhammad ShafiqAKAhmad KhanKhyber Medical CollegeMHMuhammad Zeeshan HyderCOMSATS University Islamabad

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Implication

This research investigates carbapenem-resistant Enterobacterales in uropathogens, showing higher bla NDM prevalence and antibiotic resistance levels.

Key Points

  • The study shows that 11.92% of Enterobacterales were carbapenem resistant, raising concerns about public health.
  • Among CRE isolates, 45% were positive for the bla NDM gene, predominantly found in Klebsiella pneumoniae.
  • Phylogenetic analysis indicated diverse relationships of bla NDM variants with sequences from Pakistan and globally.
  • The findings highlight the urgent need for monitoring and antibiotic stewardship due to rising carbapenem resistance.

Cite This Study

Shafiq et al. (2025) studied this question.

synapsesocial.com/papers/68ef858cc6a308ba0635563dhttps://doi.org/10.18502/ijm.v17i5.19883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular characterization of blaNDM and other carbapenemases genes among carbapenem-resistant Enterobacterales from community-and hospital- acquired urinary tract infections2025
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  3. 3Global phylogeography and genomic characterization of <i>bla</i> <sub>NDM-1</sub> -positive clinical <i>Proteus mirabilis</i> isolates from China2025
  4. 4Plasmid genomic epidemiology of bla NDM carbapenemase-producing Enterobacterales in Canada from 2010 to 20232025
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