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September 23, 2025mSystemsOpen Access

Global phylogeography and genomic characterization of bla NDM-1 -positive clinical Proteus mirabilis isolates from China

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Authors

JGJingyi GuoHXHaotian XuZhejiang Chinese Medical UniversityCWChengjin Wu

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Implication

Analysis outlines transmission dynamics and resistance mechanisms of bla NDM-1 in Proteus mirabilis, emphasizing genomic surveillance.

Key Points

  • The study reveals ST135 as the most common bla NDM-1-producing clone in China, indicating its widespread prevalence.
  • Findings show that bla NDM-1 is disseminated mainly through plasmids and SGI1, highlighting unique resistance mechanisms.
  • Comprehensive genomic analysis of CRPM isolates reinforces the importance of enhanced genomic surveillance practices worldwide.
  • Discovery of a novel SGI1-PM16 variant adds a new dimension to understanding genetic diversity within bla NDM-1-harboring isolates.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7ed09https://doi.org/10.1128/msystems.00758-25
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