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September 10, 2025ChemistrySelect

Synthesis, Characterization, Computational Studies and In Vitro Biological Effects of Novel Pyrazoles, Pyridazines, Thiazoles Containing a Quinazoline Scaffold

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Authors

AAAisha A. AlsfoukIOIsmail M. M. OthmanHNHamdi M. D. Nasr

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Overview

Novel pyrazole derivatives exhibited antimicrobial activity in microorganisms, suggesting potential therapeutic applications.

Key Points

  • Pyrazole analogue 5b demonstrated significant antimicrobial potency against several bacteria, showing levels comparable to amoxicillin.
  • The derivatives showed effectiveness against fungi A. niger and C. albicans, although less potent than ketoconazole.
  • Inhibition studies revealed that derivatives 5a and 5b suppressed S. aureus DNA gyrase effectively, outperforming reference standards.
  • Computational docking indicated strong interactions of pyrazoles with DNA gyrase, supporting their potential as therapeutic agents.

Cite This Study

Alsfouk et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479ce84https://doi.org/10.1002/slct.202501583
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Also Consider

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  1. 1Exploring novel thiazolo[5,4-f]quinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights2025 · 6 citations
  2. 2Design, Synthesis, Antimicrobial Evaluation and Molecular Docking Study of Novel Fused Pyrazole‐Based Heterocycles Featuring Nitrogen and Sulfur Heteroatoms2025
  3. 3SYNTHESIS, CHARACTERISATION, AND ANTIBACTERIAL ACTIVITY OF NOVEL PYRAZOLE-LINKED TRIAZOLE DERIVATIVES2025
  4. 4Antimicrobial Potential of Novel Quinazolin‐2,4‐dione Derivatives Bearing One and/or Two Amide Moieties: In Vitro Evaluation, Molecular Docking, and Semiempirical Calculations2025
  5. 5Synthesis, Characterization and Antibacterial Activity of Pyrazole Derivatives Featuring Thiazole Frameworks2025