Design, Synthesis, Antimicrobial Evaluation and Molecular Docking Study of Novel Fused Pyrazole‐Based Heterocycles Featuring Nitrogen and Sulfur Heteroatoms

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Novel fused pyrazole-based heterocycles exhibit potent antimicrobial effects, suggesting sulfur-containing structures enhance activity.

A series of fused pyrazole-based heterocycles showed antimicrobial activity, notably thiazolidinone derivative 12.
Some compounds exhibited MICs as low as 3.125 μg/mL, comparable to standard antimicrobial agents.
Molecular docking revealed compound 19b had the strongest binding affinity to the bacterial ribosomal protein.
The findings indicate that fused frameworks and sulfur groups improve bioactivity, highlighting potential for drug development.

Alomari et al. (2025) studied this question.

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View Full Paper

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Novel fused pyrazole-based heterocycles exhibit potent antimicrobial effects, suggesting sulfur-containing structures enhance activity.

A series of fused pyrazole-based heterocycles showed antimicrobial activity, notably thiazolidinone derivative 12.
Some compounds exhibited MICs as low as 3.125 μg/mL, comparable to standard antimicrobial agents.
Molecular docking revealed compound 19b had the strongest binding affinity to the bacterial ribosomal protein.
The findings indicate that fused frameworks and sulfur groups improve bioactivity, highlighting potential for drug development.

Alomari et al. (2025) studied this question.

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