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December 8, 2025ChemistrySelect

Antimicrobial Potential of Novel Quinazolin‐2,4‐dione Derivatives Bearing One and/or Two Amide Moieties: In Vitro Evaluation, Molecular Docking, and Semiempirical Calculations

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Authors

AAAboubakr H. AbdelmonsefEAEsam AbdallaHTHussain Temairk

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Overview

Novel quinazolin‐2,4‐dione derivatives showed antibacterial activity against Gram-positive bacteria, suggesting potential new antimicrobial agents.

Key Points

  • Compounds 2b, 2c, and 4c demonstrated significant antibacterial effect on Gram-positive bacteria, enhancing prospects for clinical use.
  • The biological evaluation indicated that these novel derivatives exhibit strong antimicrobial potential, surpassing reference drugs.
  • Molecular docking studies revealed lower binding energies and improved intermolecular interactions with target enzymes.
  • This research highlights promising new leads for antimicrobial inhibitors, warranting further development in the pharmaceutical field.

Cite This Study

Abdelmonsef et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a3https://doi.org/10.1002/slct.202504022
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