Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 26, 2025Scientific ReportsOpen Access

Exploring novel thiazolo5,4-fquinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights

View Full Paper
Ask AI
Bookmark
Share

Authors

NSNanees N. SolimanAFAhmed A. FaddaHGHatem E. Gaffer

Discussion

Loading...

Member takes

Overview

Synthesis of thiazolo[5,4-f]quinoline compounds improved antimicrobial efficacy against Staphylococcus aureus and Escherichia coli, suggesting their potential in drug development.

Key Points

  • Compounds with thiazoloquinoline structures showed significant antimicrobial activity, outperforming standard drugs.
  • Key compounds displayed MIC values of 3.125–6.25 µg/mL against multiple pathogens, indicating strong efficacy.
  • Synthetic strategies involved diverse reactions with cyanoacetamide and aryl isothiocyanates to create novel derivatives.
  • Molecular docking revealed compound 19's strong affinity for bacterial targets, underscoring its potential for development.

Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/68af7df87567bf4f94ff531ahttps://doi.org/10.1038/s41598-025-16561-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis, Characterization, Computational Studies and In Vitro Biological Effects of Novel Pyrazoles, Pyridazines, Thiazoles Containing a Quinazoline Scaffold2025 · 2 citations
  2. 2Antimicrobial Potential of Novel Quinazolin‐2,4‐dione Derivatives Bearing One and/or Two Amide Moieties: In Vitro Evaluation, Molecular Docking, and Semiempirical Calculations2025
  3. 3Potent Broad‐Spectrum Antimicrobials Based on Indene‐Fused Thiazolidinone and Thiazolopyrimidine Scaffolds: Design, Synthesis, and Molecular Insights2025
  4. 4DFT and Molecular Docking Studies on Antimicrobial Active Synthetic Derivatives of Benzimidazo-quinazoline2025
  5. 5Design, Synthesis, Antimicrobial Evaluation and Molecular Docking Study of Novel Fused Pyrazole‐Based Heterocycles Featuring Nitrogen and Sulfur Heteroatoms2025