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September 10, 2025Nature CommunicationsOpen Access

Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics

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Authors

DZDongmei ZhangSYSishan YanXWXiaoyu Wu

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Overview

Research shows pericytes regulate hemodynamics in tumors, promoting metastasis in colorectal cancer patients.

Key Points

  • Increased tumor blood flow and diameter correlate with metastasis in colorectal cancer patients.
  • A specific subpopulation of pericytes in tumors is linked to hematogenous metastasis.
  • Blocking NKX2-3 in pericytes reduces blood flow and limits tumor metastasis.
  • The findings suggest potential therapeutic strategies targeting tumor vasodilation to control metastasis.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d64797dbehttps://doi.org/10.1038/s41467-025-62475-6
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