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August 3, 2025

TRPM7 Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells

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Authors

LLLanfeng LiangZZZhifeng ZhaoJCJonathan Wei Bao Chua

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Overview

Microfluidic experiments reveal TRPM7-Annexin A1 pathway assists cell motility under fluid shear stress, indicating new therapeutic targets.

Key Points

  • MAIN FINDING: The TRPM7-Annexin A1 pathway is crucial for circulating tumor cells to navigate through capillaries.
  • KEY EVIDENCE: Only breast cancer cells with high metastatic potential migrated effectively under fluid shear stress conditions.
  • APPROACH: Microfluidics mimicking microcirculatory dynamics revealed how CTCs adapt to mechanical challenges during transit.
  • SIGNIFICANCE: Targeting the TRPM7 pathway could offer new options to inhibit metastatic spread of cancer cells.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d065dhttps://doi.org/10.1101/2025.08.01.668151
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