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September 10, 2025Communications BiologyOpen Access

Apoptotic cells promote circulating tumor cell survival and metastasis

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Authors

CHCassidy E. HaganVSValerie M SheehanCRCharles M Rezanka

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Overview

Observational analysis highlights the role of apoptotic cells in circulating tumor cell survival, suggesting new therapeutic targets.

Key Points

  • Apoptotic cells promote circulating tumor cell survival, enhancing metastasis to the lungs.
  • Inhibition of apoptotic cell-induced coagulation, such as blocking Tissue Factor, significantly reduces pro-metastatic effects.
  • Presence of apoptotic cells supports circulating tumor cell survival by recruiting platelets to the metastatic niche.
  • Findings provide insights suggesting new intervention strategies to combat metastasis driven by apoptotic cells.

Cite This Study

Hagan et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f43dhttps://doi.org/10.1038/s42003-025-08541-7
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