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September 10, 2025Annals of MedicineOpen Access

Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure

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Authors

CHChing-Hui HuangCKChew‐Teng KorCCChia‐Chu Chang

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Overview

Retrospective cohort study evaluates ferritin index vs FIB-4 score for predicting MACE in heart failure patients, suggesting improved risk assessment.

Key Points

  • Patients with elevated ferritin index showed a 1.92 times higher risk of MACE compared to lower tertiles.
  • The ferritin index outperformed the FIB-4 score in predicting MACE, particularly in older adults with metabolic signals.
  • Cox regression models confirmed the ferritin index's robust association with MACE across various patient subgroups.
  • Integration of systemic inflammation and metabolic dysfunction enhances risk stratification in heart failure patients.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d647968a7https://doi.org/10.1080/07853890.2025.2540020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic impacts of fibrosis-5 index in patients with chronic heart failure2026
  2. 2Combination of the Fibrosis 4 Index and Carbohydrate Antigen 125 to Predict Morbidity and Mortality in Acute Heart Failure2025
  3. 3Liver dysfunction indices as a predictor for in-hospital mortality in acute heart failure patients2025 · 2 citations
  4. 4Prognostic Value of Different Iron Status Definitions in Congestive Heart Failure: A Retrospective MIMIC-IV Analysis of Risk Stratification and Mortality2025
  5. 5Prognostic significance of FIB-4 versus FIB-5 in non-ST-segment-elevation acute coronary syndrome2025