What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic heart failure (n=1100). Intervention: Low FIB-5 index (combined with moderate FIB-4 index) vs. Low FIB-4 index. Primary outcome: Composite events (cardiac death and rehospitalization for heart failure) (HR 2.792, 95% CI 1.671-4.668, p=<0.001).

What question did this study set out to answer?

To evaluate the prognostic usefulness of the Fibrosis-5 index in chronic heart failure and assess its combination with the Fibrosis-4 index for better risk stratification.

June 20, 2026Heart and Vessels

Low FIB-5 and moderate FIB-4 linked to ~179% higher major event risk vs low FIB-4.

Q: What are the key findings of this study?

A low FIB-5 index combined with a moderate FIB-4 index was associated with a significantly higher risk of cardiac death and rehospitalization for heart failure compared to a low FIB-4 index (HR 2.792).

Q: What question did this study set out to answer?

To evaluate the prognostic usefulness of the Fibrosis-5 index in chronic heart failure and assess its combination with the Fibrosis-4 index for better risk stratification.

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Why the study?

Does a low FIB-5 index predict a higher rate of all-cause mortality and heart failure rehospitalization in patients with chronic heart failure?

Population

1,100 patients with chronic heart failure, mean age 78 years, 58.2% male.

Comparison

Low FIB-5 index (< -0.85) vs High FIB-5 index

Design

Cohort

Follow-up

1 year

Key result

A low FIB-5 index combined with a moderate FIB-4 index was associated with a significantly higher risk of cardiac death and rehospitalization for heart failure compared to a low FIB-4 index (HR 2.792).

Authors

SUSaori Uchiyama YKYoshiaki Kubota TNTakuya Nishino

Discussion

Member takes

Overview

May aid HF risk stratification; leaves open incremental value of combining FIB-5 with FIB-4.

Key Points

To evaluate the prognostic usefulness of the Fibrosis-5 index in chronic heart failure and assess its combination with the Fibrosis-4 index for better risk stratification.
Single-center retrospective cohort study
Included 1,100 patients from inpatient database
Utilized receiver operating characteristic curve analysis and multivariable Cox regression for endpoint assessment.
Low FIB-5 (<−0.85) is associated with significantly higher composite event rates (all-cause mortality and rehospitalization) compared to high FIB-5.
High FIB-5 values in moderate-risk FIB-4 patients showed outcomes similar to low-risk patients, while low FIB-5 values resembled high-risk outcomes.
FIB-5 serves as a useful prognostic marker, enhancing risk stratification using routine laboratory parameters.

Study Design

Type

Cohort (n=1,100)

Structured PICO

Does a low FIB-5 index predict a higher rate of all-cause mortality and heart failure rehospitalization in patients with chronic heart failure?

Population

1,100 patients with chronic heart failure discharged alive were followed for 1 year to assess the prognostic impact of the FIB-4 and FIB-5 indices.

Exposure

Low FIB-5 index (< -0.85)

Comparator

High FIB-5 index

Outcome

Composite event of all-cause mortality and rehospitalization for heart failure within 1 year of hospital dischargecomposite

Main Result

Hazard Ratio: 2.792 (95% CI 1.671–4.668)

p-value: p=<0.001

The FIB-5 index is a useful prognostic marker in chronic heart failure, and combining it with FIB-4 enhances risk stratification, particularly in moderate-risk patients.

Cite This Study

Uchiyama et al. (2026) conducted a cohort in Chronic heart failure (n=1,100). Low FIB-5 index (combined with moderate FIB-4 index) vs. Low FIB-4 index was evaluated on Composite events (cardiac death and rehospitalization for heart failure) (HR 2.792, 95% CI 1.671-4.668, p=<0.001). A low FIB-5 index combined with a moderate FIB-4 index was associated with a significantly higher risk of cardiac death and rehospitalization for heart failure compared to a low FIB-4 index (HR 2.792).

synapsesocial.com/papers/6a3722cb01fe431c251889c0 https://doi.org/10.1007/s00380-026-02724-w

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June 20, 2026Heart and Vessels

Low FIB-5 and moderate FIB-4 linked to ~179% higher major event risk vs low FIB-4.

View Full Paper

Ask AI

Bookmark

Why the study?

Does a low FIB-5 index predict a higher rate of all-cause mortality and heart failure rehospitalization in patients with chronic heart failure?

Population

1,100 patients with chronic heart failure, mean age 78 years, 58.2% male.

Comparison

Low FIB-5 index (< -0.85) vs High FIB-5 index

Design

Cohort

Follow-up

1 year

Key result

Authors

SUSaori Uchiyama YKYoshiaki Kubota TNTakuya Nishino

Discussion

Member takes

Overview

May aid HF risk stratification; leaves open incremental value of combining FIB-5 with FIB-4.

Key Points

To evaluate the prognostic usefulness of the Fibrosis-5 index in chronic heart failure and assess its combination with the Fibrosis-4 index for better risk stratification.
Single-center retrospective cohort study
Included 1,100 patients from inpatient database
Utilized receiver operating characteristic curve analysis and multivariable Cox regression for endpoint assessment.
Low FIB-5 (<−0.85) is associated with significantly higher composite event rates (all-cause mortality and rehospitalization) compared to high FIB-5.
High FIB-5 values in moderate-risk FIB-4 patients showed outcomes similar to low-risk patients, while low FIB-5 values resembled high-risk outcomes.
FIB-5 serves as a useful prognostic marker, enhancing risk stratification using routine laboratory parameters.

Study Design

Type

Cohort (n=1,100)

Structured PICO

Does a low FIB-5 index predict a higher rate of all-cause mortality and heart failure rehospitalization in patients with chronic heart failure?

Population

1,100 patients with chronic heart failure discharged alive were followed for 1 year to assess the prognostic impact of the FIB-4 and FIB-5 indices.

Exposure

Low FIB-5 index (< -0.85)

Comparator

High FIB-5 index

Outcome

Composite event of all-cause mortality and rehospitalization for heart failure within 1 year of hospital dischargecomposite

Main Result

Hazard Ratio: 2.792 (95% CI 1.671–4.668)

p-value: p=<0.001

The FIB-5 index is a useful prognostic marker in chronic heart failure, and combining it with FIB-4 enhances risk stratification, particularly in moderate-risk patients.

Cite This Study

synapsesocial.com/papers/6a3722cb01fe431c251889c0 https://doi.org/10.1007/s00380-026-02724-w

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