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September 10, 2025PLoS ONEOpen Access

Fibrosis-4 index as a predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease

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Authors

ZZZ.-H. ZhuKRKejun RenXDXiaowei Duan

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Overview

Analysis shows Fibrosis-4 index predicts all-cause and cardiovascular mortality in CKD patients, suggesting important clinical insights.

Key Points

  • Each 1-unit increase in the Fibrosis-4 index raises the risk of all-cause mortality by 34%.
  • Weighted logistic regression confirmed Fibrosis-4 as a significant predictor of CKD risk with an odds ratio of 1.85.
  • Receiver operating characteristic analysis demonstrated strong predictive performance with AUC values of 0.799 for all-cause mortality.
  • Subgroup analyses revealed higher mortality risks for non-Hispanic Black individuals and older adults.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d64796347https://doi.org/10.1371/journal.pone.0329315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic significance of FIB-4 versus FIB-5 in non-ST-segment-elevation acute coronary syndrome2025
  2. 2Prognostic impacts of fibrosis-5 index in patients with chronic heart failure2026
  3. 31427-P: Fibrosis-4 Index Is Associated with ASCVD Burden, MACE, and Mortality in Real-World Type 2 Diabetes Cohort2026
  4. 4Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure2025
  5. 5Combination of the Fibrosis 4 Index and Carbohydrate Antigen 125 to Predict Morbidity and Mortality in Acute Heart Failure2025