September 10, 2025Toxicology Research

Puerarin alleviates high glucose-induced lens epithelial cell damage by activating the Nrf2 Signaling pathway to inhibit oxidative stress

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Authors

JXJuan Xia MZMingli Zhou YMYongxin MaChinese Academy of Sciences

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Implication

Observational analysis shows Puerarin reduces oxidative stress and apoptosis in lens epithelial cells, indicating its potential use in diabetes treatment.

Key Points

Puerarin significantly restores cell viability in lens epithelial cells exposed to high glucose.
Both 20 μM and 50 μM Puerarin doses reduced apoptosis and oxidative stress markers in treated cells.
Knockdown of Nrf2 abolished Puerarin's protective effects, showing its crucial role in cell defense mechanisms.
High glucose exposure contributes to oxidative stress in lens epithelial cells, highlighting the importance of antioxidant interventions.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d647955c5 https://doi.org/10.1093/toxres/tfaf109

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Implication

Observational analysis shows Puerarin reduces oxidative stress and apoptosis in lens epithelial cells, indicating its potential use in diabetes treatment.

Puerarin alleviates high glucose-induced lens epithelial cell damage by activating the Nrf2 Signaling pathway to inhibit oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

Puerarin alleviates high glucose-induced lens epithelial cell damage by activating the Nrf2 Signaling pathway to inhibit oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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