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September 10, 2025BMC NephrologyOpen Access

The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells

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Authors

XJXiaocui JiaoYLYing LiDWDi Wu

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Overview

Observational analysis reveals kaempferol improves cell viability in high glucose exposures, suggesting potential in diabetic nephropathy therapy.

Key Points

  • Kaempferol significantly enhances HK-2 cell viability when exposed to high glucose stress.
  • Results showed increased levels of Sirt3 and improved oxidative stress markers in the presence of kaempferol.
  • Western blot analysis indicated enhanced activation of the Akt/FoxO3a signaling pathway with kaempferol treatment.
  • The findings suggest that targeting oxidative stress and apoptosis could provide new strategies for managing diabetic nephropathy.

Cite This Study

Jiao et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a482chttps://doi.org/10.1186/s12882-025-04404-9
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