August 15, 2025BMC OphthalmologyOpen Access

Protective effects of pituitary adenylate cyclase-activating peptide (PACAP) on high glucose-induced damage in human corneal epithelial cell

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Authors

YBYanan Bao BLBing Li

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Implication

Laboratory assessment reveals PACAP38 restores cell proliferation and migration in high glucose-exposed human corneal epithelial cells, indicating its role in diabetic keratopathy treatment.

Key Points

PACAP38 treatment restores cell viability in human corneal epithelial cells exposed to high glucose, counteracting detrimental effects.
Compared to the normal control group, high glucose significantly suppressed cell proliferation and migration (p < 0.01).
Analysis using various methodologies shows PACAP38 activates AMPK/ERK signaling, enhancing autophagy and cell survival despite hyperglycemia.
These findings support the potential of PACAP38 as a therapeutic candidate for managing diabetic keratopathy.

Cite This Study

Bao et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4dee https://doi.org/10.1186/s12886-025-04309-z

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Implication

Laboratory assessment reveals PACAP38 restores cell proliferation and migration in high glucose-exposed human corneal epithelial cells, indicating its role in diabetic keratopathy treatment.

Protective effects of pituitary adenylate cyclase-activating peptide (PACAP) on high glucose-induced damage in human corneal epithelial cell

Discussion

Member takes

Implication

Key Points

Cite This Study

Protective effects of pituitary adenylate cyclase-activating peptide (PACAP) on high glucose-induced damage in human corneal epithelial cell

Discussion

Member takes

Implication

Key Points

Cite This Study

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