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September 10, 2025European Journal of Dermatology

Diagnostic and therapeutic impact of miR-142, miR-146a, and miR-155 on cutaneous T-cell lymphoma

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Authors

MPMarianna PapadakiNational and Kapodistrian University of AthensMBMarilena M. BourdakouCyprus Institute of Neurology and GeneticsCPChristina PiperiNational and Kapodistrian University of Athens

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Implication

Observational analysis reveals miR-142, miR-146a, and miR-155 as potential biomarkers in mycosis fungoides, indicating non-invasive diagnostic applications.

Key Points

  • Significant upregulation of miR-142, miR-146a, and miR-155 in early-stage mycosis fungoides patients was observed.
  • Analysis showed p<0.05 for miRNA expression differences between patients and controls, highlighting diagnostic potential.
  • Using antagomirs to downregulate these miRNAs significantly decreased malignant cell proliferation and increased apoptosis.
  • Findings suggest that liquid biopsy for miR-142, miR-146a, and miR-155 may provide a novel, non-invasive diagnostic method.

Cite This Study

Papadaki et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479507dhttps://doi.org/10.1684/ejd.2025.4887
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic landscape of mycosis fungoides2025
  2. 2Integrative Mutational Landscape of Mycosis Fungoides Using a National Genomics Repository2025 · 5 citations
  3. 3Immune pathways, current and potential therapies in Mycosis fungoides and Sezary syndrome2025 · 2 citations
  4. 4miRNA-155-3p and miRNA-3196 as Potential Biomarkers in Liquid Biopsies of Non-Small Cell Lung Cancer Patients2025 · 1 citations
  5. 5Serum mirnas predict response to CAR-T cell therapy in large B-cell lymphoma2025