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December 8, 2025BloodOpen Access

Genomic landscape of mycosis fungoides

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Authors

VRVeronica RussellKNKikkeri N. NareshETElizabeth Thacker

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Overview

Multi-center genomic analysis reveals poor progression-free survival in mycosis fungoides, indicating significant genomic markers and ancestry implications.

Key Points

  • Mycosis fungoides was linked to poor progression-free survival and high expression of cell cycle pathways when large-cell transformation was present.
  • Key alterations included copy number variants affecting TP53 and ARID1A mutations in black patients, highlighting genomic diversity.
  • Gene set enrichment analysis revealed cell cycle and inflammatory pathways that differed significantly across patient subgroups.
  • Findings recommend further exploration of identified genomic markers as potential treatment targets in advanced mycosis fungoides.

Cite This Study

Russell et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d571https://doi.org/10.1182/blood-2025-7062
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative Mutational Landscape of Mycosis Fungoides Using a National Genomics Repository2025 · 5 citations
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  3. 3Single-cell RNA sequencing identifies subtypes of cancer-associated fibroblasts in early and late stages of mycosis fungoides.2025
  4. 4Identifying biological differences between two clinical risk groups of cutaneous CD30+ T cell lymphoproliferative disorders2025
  5. 5Racial disparities in mycosis fungoides - from self-reported race to genetic ancestry analysis2025 · 1 citations