December 8, 2025BloodOpen Access

Serum mirnas predict response to CAR-T cell therapy in large B-cell lymphoma

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Discussion

Retrospective analysis shows predictive models using serum miRNAs can assess CAR-T effectiveness and prognosis in large B-cell lymphoma.

Patients with high expression of predictive miRNAs showed enhanced progression-free survival post-CAR-T therapy, indicating potential treatment success.
Predictive models assessing miRNAs achieved significant AUC values, particularly for complete response at various time points, demonstrating clinical relevance.
Logistic regression was used to optimize predictive models based on four serum miRNAs measured with digital PCR, reflecting their importance in therapy outcomes.
Integrating miRNA analysis into clinical practice may improve decision-making for CAR-T treatment in patients with large B-cell lymphoma.

Sheng et al. (2025) studied this question.

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