Prospective trial identifies mucosal-associated invariant T cells as biomarkers for GI aGVHD, suggesting precision prevention strategies.
Key Points
This study aims to identify immune features of graft-derived MAIT cells that predict the risk of gastrointestinal graft-versus-host disease after transplantation.
Prospective analysis of MAIT-cell phenotypes in peripheral blood stem cell grafts using spectral flow cytometry.
Single-cell RNA sequencing and murine models to explore MAIT-cell functions.
Development of a predictive panel based on MAIT-cell functional markers.
Higher graft MAIT-cell abundance correlated with a lower risk of GI aGVHD.
The predictive panel achieved an area under the curve of 0.80, improving to 0.85 after covariate adjustment.
Findings support MAIT cells as biomarkers for pre-transplant risk assessment.