September 5, 2025Nature CommunicationsOpen Access

Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification

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Discussion

Experimental analysis shows diverse aminoglycoside efficacy in resistant bacteria, highlighting rRNA methylation's variable effects.

Aminoglycosides still retain potency against some resistant strains, indicating variable impact of m1A1408 methylation.
High-resolution structures of ribosome-aminoglycoside complexes reveal critical resistance evasion mechanisms based on conformational adaptations.
Molecular dynamics simulations illustrate how specific ring substituents and functional group interactions influence drug efficacy.
These findings provide foundational design principles for developing aminoglycosides that are resistant to RNA modification-induced resistance.

Dey et al. (2025) studied this question.

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