Comprehensive analysis reveals adaptive responses of Escherichia coli, Staphylococcus aureus, and others to antibiotics, indicating mechanisms of antibiotic tolerance.
Key Points
Proteomic and metabolomic analysis showed minimal changes in the proteome of some pathogens under antibiotic stress.
Trimethylamine metabolism was consistently altered across Escherichia coli and other bacterial species, suggesting survival adaptations.
Shared responses to chloramphenicol include alterations in translation, oxidative stress management, and biofilm formation.
Findings highlight critical proteins and metabolites that contribute to antimicrobial resistance mechanisms.