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September 10, 2025Journal of Biochemical and Molecular Toxicology

Inhibition of Linc00284 Enhances Radiosensitivity in Colorectal Cancer Through miR‐559/c‐Myc Axis

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Authors

FDFeng DongWWWei WuXZXinyi Zhang

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Overview

Experimental analysis demonstrates that silencing Linc00284 enhances radiosensitivity in colorectal cancer, implicating miR-559 and c-Myc in the process.

Key Points

  • Silencing Linc00284 enhances colorectal cancer radiosensitivity, showing significant therapeutic potential.
  • Linc00284 expression was correlated with patient radiosensitivity, emphasizing its importance as a biomarker.
  • Cell proliferation assays confirmed that targeting Linc00284 influences miR-559 and c-Myc expression in CRC cells.
  • This study suggests that Linc00284 may be a valuable target in overcoming radioresistance in colorectal cancer.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d64793cc4https://doi.org/10.1002/jbt.70410
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