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December 6, 2025Cellular and Molecular Life SciencesOpen Access

LINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer

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Authors

JLJunping LeiLWLin WangTXTian Xia

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Overview

Analysis reveals LINC02878 promotes tumor progression in colorectal cancer, indicating it may serve as a therapeutic target.

Key Points

  • Inhibition of LINC02878 leads to reduced tumor growth and metastasis in colorectal cancer.
  • Knockdown of this oncogenic lncRNA improved prognosis in preclinical xenograft models of CRC.
  • The study highlights tumor growth as a significant outcome in advanced stages of colorectal cancer.
  • Identifying the LINC02878/ZNF282/PYCR2 axis calls for new therapeutic targets to manage CRC.

Cite This Study

Lei et al. (2025) studied this question.

synapsesocial.com/papers/69337cefb3f947a0a125a309https://doi.org/10.1007/s00018-025-05968-3
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