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September 10, 2025Acta Biochimica et Biophysica SinicaOpen Access

LINC00114 promotes colorectal cancer metastasis by targeting HNRNPA1 to regulate glutamine metabolism reprogramming and angiogenesis

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Authors

STShiyu TangMLMeng LiuYZYangyang Zhu

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Overview

Research shows LINC00114 enhances glutamine metabolism and angiogenesis in colorectal cancer, suggesting targeting it may inhibit metastasis.

Key Points

  • LINC00114 significantly enhances colorectal cancer metastasis by targeting HNRNPA1, implicating new therapeutic avenues.
  • RNA-binding-protein immunoprecipitation revealed strong binding between LINC00114 and HNRNPA1, enhancing its expression.
  • Treatment with si-LINC00114 significantly decreased proliferation and angiogenesis in CRC cells and HUVECs, pointing to its critical role.
  • Animal studies demonstrated that LINC00114 intervention reduced CRC progression and altered glutamine metabolism, indicating its significance.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68c242cbb210217d647a4500https://doi.org/10.3724/abbs.2025141
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